Emmanuelle Comets
University Paris Diderot - Site Bichat
16, rue Henri Huchard
75018 Paris
Nonlinear mixed effect models, with an emphasis on:
- Pharmacogenetics
- Model evaluation
- Design optimisation
- Parameter estimation
- Pharmacogenetics
- Model evaluation
- Design optimisation
- Parameter estimation
Bertrand J, Comets E, Laffont C, Chenel M, Mentré F.
Journal of Pharmacokinetics and Pharmacodynamics 2009, 36, 317-39. Link to abstract
Design optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics.
Retout S, Comets E, Bazzoli C, Mentré F.
Communications in Statistics –Theory and Methods. 2009 in press Link to abstract
A survey of the way pharmacokinetics are reported in published phase I clinical trials, with an emphasis on oncology.
Comets E, Zohar S.
Clinical Pharmacokinetics, 2009, 48, 387-395. Link to publication
Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters.
Bertrand J, Comets E, Mentré F.
Journal of Biopharmaceutical Statistics , 2008, 18, 1084-1102. Link to publication
Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R.
Comets E, Brendel K, Mentré F.
Computer Methods and Programs in Biomedicine, 2008, 90, 154-166. Link to publication
Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.
Brendel K, Comets E, Laffont C, Laveille C, Mentré F.
Pharmaceutical Research, 2006, 23, 2036-2049. Link to publication
- William Couët, INSERM ERI 23 Pharmacologie des anti-infectieux , Poitiers
- Sandrine Delpierre, Service de gériatrie, Hôpital Beaujon - Corine Miceli-Richard, INSERM U802, Bicêtre
- Céline Verstuyft, INSERM EA 2706 Barrière et passage des médicaments , Bicêtre
- Sarah Zohar, Université Paris-Diderot