Emmanuelle Comets
 
  Emmanuelle Comets Position Researcher (CR1 INSERM)  
  Contact emmanuelle.comets@inserm.fr  
    INSERM UMR 738 - Institut Claude Bernard
University Paris Diderot - Site Bichat
16, rue Henri Huchard
75018 Paris
 
     
     
       
     
 
  Reasearch interests
Nonlinear mixed effect models, with an emphasis on:
- Pharmacogenetics
- Model evaluation
- Design optimisation
- Parameter estimation
 
     
     
     
     
         
  Selected publications Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm.
Bertrand J, Comets E, Laffont C, Chenel M, Mentré F.
Journal of Pharmacokinetics and Pharmacodynamics 2009, 36, 317-39. Link to abstract

Design optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics.
Retout S, Comets E, Bazzoli C, Mentré F.
Communications in Statistics –Theory and Methods. 2009 in press Link to abstract


A survey of the way pharmacokinetics are reported in published phase I clinical trials, with an emphasis on oncology.
Comets E, Zohar S.
Clinical Pharmacokinetics, 2009, 48, 387-395. Link to publication

Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters.
Bertrand J, Comets E, Mentré F.
Journal of Biopharmaceutical Statistics , 2008, 18, 1084-1102. Link to publication

Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R.
Comets E, Brendel K, Mentré F.
Computer Methods and Programs in Biomedicine, 2008, 90, 154-166. Link to publication

Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.
Brendel K, Comets E, Laffont C, Laveille C, Mentré F.
Pharmaceutical Research, 2006, 23, 2036-2049. Link to publication

 
         
  Collaborations - Karl Brendel, I.R.I.S. Servier
- William Couët, INSERM ERI 23 Pharmacologie des anti-infectieux , Poitiers
- Sandrine Delpierre, Service de gériatrie, Hôpital Beaujon - Corine Miceli-Richard, INSERM U802, Bicêtre
- Céline Verstuyft, INSERM EA 2706 Barrière et passage des médicaments , Bicêtre
- Sarah Zohar, Université Paris-Diderot
 
         
  Courses R introductory course and reference guide (under Teaching tab)  
         
  Software Model evaluation using npde : npde package for the R software  
         
         

Last update: 09/05/10