Hervé Le Nagard
University Paris Diderot - Site Bichat
16, rue Henri Huchard
75018 Paris
I'm interested in evolutionary algorithms to study the emergence of complexity and modularity in artificials organisms.
While the emergence of complexity is a key question in evolution, complexity of living organisms or of their constitutive parts such as genetic networks is poorly defined. I'm using artificial networks to validate the usage of some estimator of complexity based on the way organisms perceive their environment through the unifying perspective of natural selection.
While the emergence of complexity is a key question in evolution, complexity of living organisms or of their constitutive parts such as genetic networks is poorly defined. I'm using artificial networks to validate the usage of some estimator of complexity based on the way organisms perceive their environment through the unifying perspective of natural selection.
Billard-Pomares T, Tenaillon O, Le Nagard H, Rouy Z, Cruveiller S, Médigue C, Arlet G, Denamur E, Branger C.
Antimicrob Agents Chemother. 2011 Mar;55(3):1270-3. Epub 2010 Dec 20.
Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections.
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, Balliau T, Zivy M, Le Nagard H, Cruvellier S, Chane-Woon-Ming B, Nilsson S, Gudelj I, Phan K, Ferenci T, Tenaillon O, Denamur E.
PLoS Pathog. 2010 Sep 30;6(9). pii: e1001125.
Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression.
Le Nagard H, Vincent C, Mentré F, Le Bras J.
Comput Methods Programs Biomed. 2010 Sep 7. [Epub ahead of print]
The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation.
Gros PA, Le Nagard H, Tenaillon O.
Genetics. 2009 May;182(1):277-93. Epub 2009 Mar 11.
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Mutators and sex in bacteria: conflict between adaptive strategies.
Tenaillon O, Le Nagard H, Godelle B, Taddei F.
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10465-70.
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Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B.
Genetics. 1999 Jun;152(2):485-93.
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