Hervé Le Nagard
  Hervé Le Nagard Position Computer Engineer  
  Contact herve.lenagard@inserm.fr  
    UMR 738 - Institut Claude Bernard
University Paris Diderot - Site Bichat
16, rue Henri Huchard
75018 Paris
  Reasearch interests
I'm interested in evolutionary algorithms to study the emergence of complexity and modularity in artificials organisms.
While the emergence of complexity is a key question in evolution, complexity of living organisms or of their constitutive parts such as genetic networks is poorly defined. I'm using artificial networks to validate the usage of some estimator of complexity based on the way organisms perceive their environment through the unifying perspective of natural selection.
  Selected publications The emergence of complexity and restricted pleiotropy in adapting networks
Le Nagard H, Chao L, Tenaillon O
BMC Evolutionary Biology 2011 Nov;11:326

Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression.
Le Nagard H, Vincent C, Mentré F, Le Bras J.
Comput Methods Programs Biomed. 2011 Oct;104(1):10-8. Epub 2010 Sep 9.

Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.
Billard-Pomares T, Tenaillon O, Le Nagard H, Rouy Z, Cruveiller S, Médigue C, Arlet G, Denamur E, Branger C.
Antimicrob Agents Chemother. 2011 Mar;55(3):1270-3. Epub 2010 Dec 20.

Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections.
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, Balliau T, Zivy M, Le Nagard H, Cruvellier S, Chane-Woon-Ming B, Nilsson S, Gudelj I, Phan K, Ferenci T, Tenaillon O, Denamur E.
PLoS Pathog. 2010 Sep 30;6(9). pii: e1001125.

The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation.
Gros PA, Le Nagard H, Tenaillon O.
Genetics. 2009 May;182(1):277-93. Epub 2009 Mar 11.
Link to text

Mutators and sex in bacteria: conflict between adaptive strategies.
Tenaillon O, Le Nagard H, Godelle B, Taddei F.
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10465-70.
Link to text

Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B.
Genetics. 1999 Jun;152(2):485-93.
Link to text

  Collaborations The World Wide Antimalarial Resistance Network  
  Software The PFIM Project  
  Links ICEstimator

Last update: 10/24/21