France Mentré
  France Mentré Position Professor of Biostatistics  
    UMR_S 738: INSERM and University Paris Diderot
Team 1: Biostatistical Modelling and Pharmacometrics
School of Medicine- site Bichat
16 rue Henri Huchard
75018 Paris, France
  Reasearch interests
Methods in Pharmacometrics and biostatistical modelling:
- optimal design approaches (e.g. PFIM)
- tools for model evaluation (e.g. npde)
- test for covariates and model building
- modelling for biosimilarity evaluation
- modelling for analysis of clinical trials
Application of modelling and pharmacometrics:
- pharmacokinetics and pharmacogenetics of antiretrovirals
- modelling emergence of resistance to antibiotics
- estimation of resistance to antimalarials
  Selected publications TEN MAIN PUBLICATIONS (2010-2012)
Savic RM, Barrail-Tran A, Duval X, Nembot G, Panhard X, Descamps D, Verstuyft C, Vrijens B, Taburet AM, Goujard C, Mentré F. Effect of adherence as measured by MEMS, ritonavir boosting, and CYP3A5 genotype on atazanavir pharmacokinetics in treatment-naive HIV-infected Patients. Clinical Pharmacology and Therapeutics, 2012, 92:575-583
Dubois A, Gsteiger S, Balser S, Pigeolet E, Steimer JL, Pillai C, Mentré F. Analysis of pharmacokinetic similarity of biologics using nonlinear mixed effects modelling. Clinical Pharmacology and Therapeutics, 2012, 91, 234-242.
Nguyen TT, Bazzoli C, Mentré F.Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models. Statistics in Medicine, 2012, 31, 1043-1058.
Bertrand J, Comets E, Chenel M, Mentré F. Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models. Biometrics, 2012, 68:146-155.
Comets E, Diquet B, Legrain S, Huisse MG, Godon A, Bruhat C, Chauveheid MP, Delpierre S, Duval X, Berrut G, Verstuyft C, Aumont MC, Mentré F. Pharmacokinetic and pharmacodynamic variability of fluindione in octogenarians. Clinical Pharmacology and Therapeutics, 2012, 91:777-786.
Bazzoli C, Benech H, Rey E, Retout S, Salmon D, Duval X, Tréluyer JM, Mentré F and the COPHAR2-ANRS111 study group. Population joint pharmacokinetic analysis of zidovudine, lamivudine and their active intracellular metabolites in HIV patients. Antimicrobial Agents and Chemotherapy, 2011, 55, 2423-3431.
Lavielle M, Samson A, Fermin AK, Mentré F. Maximum likelihood estimation of long term HIV dynamic models and antiviral response. Biometrics, 2011, 67, 250-259.
Guedj J, Bazzoli C, Neumann A, Mentré F. Design evaluation and optimization for models of hepatitis C viral dynamics. Statistics in Medicine, 2011, 30:1045-1056.
Bazzoli C, Retout S, Mentré F. Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0. Computer Methods and Programs in Biomedicine, 2010, 98:55-65.
Brendel K, Comets E, Laffont C, Mentré F. Evaluation of different tests based on observations for external model evaluation of population analyses. Journal of Pharmacokinetics and Pharmacodynamics, 2010, 37:49-65
  Software PFIM:
IC50 estimator:

Last update: 07/27/17